Cancer lineage

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August undefined, 2024

WebAug 4, 2024 · Lineage transformation between lung cancer subtypes is a poorly understood phenomenon associated with resistance to treatment and poor patient outcomes. Here, we aimed to model this transition to define underlying biological mechanisms and identify potential avenues for therapeutic intervention. Small cell lung cancer (SCLC) is … WebJun 24, 2024 · Combining single-cell lineage tracing with RNA sequencing has provided unprecedented opportunities to prospectively explore metastatic dynamics in vivo. In this issue of Cancer Cell, Simeonov et al. …

Biologists discover a transmissible cancer lineage in Far …

WebMar 30, 2024 · An international research team, including biologists from St Petersburg University, has identified a transmissible cancer lineage in the Far Eastern mussels. The disease can have an adverse effect ... WebMar 9, 2024 · Cancer cell plasticity can be operationally defined as the ability of a cell to substantially modify its identity and take on a new phenotype that more closely … dwyer lexington ky

Cancer Therapeutics Response Portal - Broad Institute

WebMar 9, 2024 · Lineage plasticity is a source of intratumoural heterogeneity and enables tumour adaptation to an adverse tumour microenvironment, eventually leading to therapeutic resistance. The authors of this ... WebApr 12, 2024 · While studying a type of bacteria that lives on the healthy skin of every human being, researchers from Stanford Medicine and a colleague may have stumbled … Web2 days ago · Rick Wolff, the longtime host of WFAN’s Sunday morning program “The Sports Edge,” died Monday at 71 after a short battle with brain cancer. The news was … dwyer lori

LinRace: single cell lineage reconstruction using paired lineage ...

Volume 6, 2024 Annual Review of Cancer Biology

WebThe Cancer Therapeutics Response Portal v1 provides open access to the results obtained through quantitatively measuring the sensitivity of 242 genetically characterized cancer-cell lines to a 354-member ‘Informer Set’ of small-molecule probes and drugs. Statistically significant correlations identified between the genetic and lineage ... WebAug 2, 2024 · The canine transmissible venereal tumor (CTVT) is a cancer lineage that arose several millennia ago and survives by "metastasizing" between hosts through cell transfer. The somatic mutations in this cancer record its phylogeography and evolutionary history. We constructed a time-resolved phylogeny from 546 CTVT exomes and describe … dwyer landscaping louisvilleWebApr 4, 2024 · Discovering mechanisms that control lineage identity could provide novel avenues for mitigating disease progression. Here we report that the transcriptional … crystal method song list

"WebOct 5, 2024 · In related work, Ku et al. found that prostate cancer metastasis, lineage switching, and drug resistance were driven by the combined loss of the same tumor suppressors and were accompanied by ... " - Cancer lineage

Cancer lineage

Lineage plasticity in cancer: a shared pathway of therapeutic ...

WebOct 3, 2024 · According to the American Cancer Society, most patients with acute myeloid leukemia (AML) have too many immature white cells in their blood, and not enough red blood cells or platelets. ... While both myeloid … WebApr 11, 2024 · Abstract. Lineage plasticity, a cell's capacity to switch lineage-restricted gene expression states, is required for normal tissue homeostasis. Cancer lineage plasticity is increasingly observed ...

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WebAmong multiple factors preventing effective therapeutic responses, a poorly understood tumor-intrinsic metabolic heterogeneity across different cancers, arising potentially from diverse microenvironmental or lineage-specific factors, may preclude effective therapeutic strategies to target cancer metabolism. WebApr 14, 2024 · Abstract. The reprogramming of malignant cells to pluripotency has presented considerable challenges, hindering the application of induced pluripotent stem cell (iPSC) modeling technology to human cancers. In addition, how well iPSC-derived cells resemble their primary counterparts is currently largely unknown. We developed a …

WebOct 11, 2024 · Lineage plasticity is a critical mechanism of therapeutic resistance in cancer. In a recent issue of Science, Chan and colleagues demonstrate that early lineage … WebApr 7, 2024 · Mosaic mutations can be used to track cell ancestries and reconstruct high-resolution lineage trees during cancer progression and during development, starting from the first cell divisions of the zygote. However, this approach requires sampling and analyzing the genomes of multiple cells, which can be redundant in lineage representation ...

WebA Closer Look at Abnormal p53 and Cancer Development A cell lacking functional p53 may or may not become cancerous, and correspondingly, a cell with normal p53 function may eventually lead to the formation of a … WebDec 21, 2024 · Lineage tracing studies have become a well-suited approach to reveal cellular hierarchies and tumor heterogeneity. Cellular heterogeneity, particularly in breast …

WebCancer Research publishes original studies, reviews, and opinion pieces offering significance and broad impact to a diverse audience. Cancer Research seeks manuscripts that offer pathobiological and translational impact to inform the personal, clinical, and societal problems posed by cancer. Read More About the Journal.

WebFurther understanding the glioblastoma (GBM) tumor immune microenvironment to refine immunotherapeutic strategies is essential. Here, we show that GBM tumor cell lineage association can influence the abundance and ontogeny of tumor-associated macrophages (TAMs) in the tumor immune microenvironment. crystal method - producersWebNov 24, 2024 · Overall, we have described the phylogeny, lineage dynamics, geographical spread, and genome evolution of DFT1, providing important information for future Tasmanian devil conservation planning and illustrating how a comparatively simple and stable cancer cell lineage can colonise diverse niches and devastate a species. dwyer magnehelic 2000-00nWebApr 13, 2024 · Understanding how single cells divide and differentiate into different cell types in developed organs is one of the major tasks of developmental and stem cell biology. Recently, lineage tracing technology using CRISPR/Cas9 genome editing has enabled simultaneous readouts of gene expressions and lineage barcodes in single cells, which … dwyer magnehelic 2300 0WebMar 28, 2024 · Pediatric Blood & Cancer. Early View e30295. RESEARCH ARTICLE. A simple procedure to identify children with B-lineage acute lymphoblastic leukemia who can be successfully treated with low or moderate intensity: Sequential versus single-point minimal residual disease measurement. crystal method tough guyWeb7 Department of Pathology, Fox Chase Cancer Center, Philadelphia, PA, US. 8 Department of Clinical Pathology, Robert-Bosch-Krankenhaus, ... Continuous efforts focusing on deciphering the specific cell lineage and differentiation state of these tumors will be critical for their accurate classification. Comprehensive molecular characterization of ... crystal methods project managementWebMar 27, 2024 · Lineage transformation and therapeutic resistance in our prostate cancer models were dependent on increased expression of stem cell reprogramming factors like SOX2 and EZH2. In an analogous manner, RB1 loss may mediate upregulation of epigenetic and stem cell reprogramming factors in EGFR -mutant LUAD, facilitating … dwyer magnehelic differential pressure gaugesWebOct 7, 2024 · Drivers of lineage plasticity. The detrimental impact of cancer cell plasticity on therapy response is well documented in diverse tumour types, but the underlying … dwyer magnehelic 2000-60pa