Cisplatin hydrolysis
WebSep 24, 2024 · Cisplatin’s mechanism of action is initiated by the activation of the complex in the intracellular medium by the hydrolysis of chloride molecules. The cisplatin molecule hydrolyzes in the cytoplasm, and acts as a potent electrophilic agent, reacting with nucleic acids and sulfhydryl groups of proteins [ 14 , 15 ]. WebIts axial steric hindrance decreases the rate of substitution reactions in square planar complexes with consequent slower rates of hydrolysis and cross-link formation (with implication in terms of DNA repair) compared to cisplatin. It is orally active. View article Anticancer platinum (II) complexes bearing N-heterocycle rings
Cisplatin hydrolysis
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WebOct 10, 2002 · Cisplatin ( cis -DDP) is subject to nucleophilic displacement of chloride in water, forming aquated species, subsequently liberating hydrogen ion (s) with increasing pH. This study intends to theoretically analyze the hydrolysis and polyprotic dissociation behavior of -DDP in various aqueous media. WebSep 21, 2010 · Cisplatin, or cis-[Pt(NH(3))(2)Cl(2)], was the first member of a new revolutionary class of anticancer drugs that is still used today for the treatment of …
WebMar 24, 2003 · Cisplatin is administered to patients i.v. The physiological chloride concentration in blood and extracellular body fluids is 100 mM, which is high enough to … WebChemical basis for the detoxification of cisplatin-derived hydrolysis products by sodium thiosulfate Cisplatin remains the most widely used platinum-based anti-cancer drug and is included on the World Health Organization's list of essential medicines.
WebCisplatin Injection is a sterile, multidose vial without preservatives. Store at 15° to 25°C (59° to 77°F). Do not refrigerate. Protect unopened container from light. The cisplatin … WebCisplatin, cis - [PtCl 2 (NH 3) 2 ], is extensively used for the treatment of testicular and ovarian cancers and increasingly against other types of solid tumors (head/neck, lung, cervical, and bladder) ( 1 , 2 , 3 , 4 ). The cytotoxic effect of cisplatin is thought to be due to attack on DNA bases and induction of apoptosis in cancer cells ( 5 , 6
WebJan 11, 2024 · Cisplatin is a squared planar platinum (II) complex composed by a central metal atom coordinated with two chlorides and two ammonia molecules in a cis configuration (Figure 2 ). Even though the …
WebSep 9, 2014 · Cisplatin undergoes hydrolysis within the cell producing a highly reactive charged platinum complex [Pt(NH3)2ClH2O]+. After further hydrolysis, this complex binds to DNA bases through the N7 atom (preferably guanine). This DNA cross-linkage mechanism interferes with cell division and replication. tt results historyWebIn water, the antineoplastic drug cisplatin, cis- [PtCl2 (NH3)2] (1) hydrolyses slowly to the aqua complexes cis- [Pt (NH3)2Cl (H2O)]+ (2) and, to a small extent, cis- [Pt (NH3)2 … phoenix publishing house hiringWebJan 30, 2024 · Two typical reactions involved in the complex hydrolysis include the first and second hydrolysis processes. We have tried to show how the total energy, barrier … ttrewq112ttrewq123WebThe pharmacokinetics of cisplatin and its cytotoxic hydrolysis product cis-diammineaquachloroplatinum(II) ion (monohydrated complex) were investigated in seven patients after they received a 1-h infusion of cisplatin in normal saline at 100 mg/m2. The concentrations of intact cisplatin and the monoh … ttrewq11WebMost sources say that cisplatin is soluble in water and saline at around 1 mg/ml - 2.5 mg/ml depending on the source. I saw in the attached article (under liposome preparation method) that they... ttrewq12WebJun 1, 2015 · For obtaining stable solution of cisplatin sample containing 10 ng Pt/mL was prepared from the stock cisplatin solution in 0.9% NaCl, and injected onto the column immediately after the dilution. To identify monoaquacisplatin, which is the first hydrolysis product of cisplatin, the same solution was also injected 15 min phoenix pub london victoria