Dab2 interacting protein
WebDab2IP, also known as apoptosis signal-regulating kinase-interacting protein-1 (ASK1), is a GTPase activating protein associated with aggressive metastatic prostate cancer , … WebASK1-interacting protein-1 (AIP1) is a newly discovered signal scaffold protein, which is a member of the Ras-GTPase activating protein (Ras-GAP) family. 8 The expression of AIP1 in tumor cells is inhibited by histone-lysine N-methyltransferase EZH2 protein, 9,10 which is highly expressed in various tumor tissues and functions to promote the ...
Dab2 interacting protein
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WebFeb 15, 2024 · Abstract. Disabled-2 (Dab2/DOC-2) is a mitogen-responsive adaptor protein required for multiple cellular functions. It is involved in many signaling pathways and plays an integral role in vesicular uptake and trafficking, modulating immune function, protein … WebFeb 9, 2012 · This indicates that the interaction between Dab2 and a DPF-interacting protein is essential for Dab2 function when AP2 levels are low. This DPF-interacting …
WebMechanistically, DAB2 interacting protein (DAB2IP) was screened as a direct target of miR-1307-3p. The expression of DAB2IP mRNA was down-regulated and inversely … WebOct 18, 2024 · Some GAPs can promote apoptosis of tumor cells to protect the organism. p120RasGAP, regulator of G-protein signaling 3 (RGS3), deleted in liver cancer 1 (DLC1), DOC-2/DAB2 interacting protein (DAB2IP), and STARD13 are typical examples because the five GAPs can influence the balance of antiapoptotic proteins and proapoptotic …
WebSep 17, 2024 · Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein family, and functions as a … Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene. DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005).[supplied by OMIM]
WebSep 26, 2024 · Orthologous to human DAB2IP (DAB2 interacting protein). [provided by Alliance of Genome Resources, Apr 2024] Other designations. disabled homolog 2-interacting protein, ASK-interacting protein 1, ASK1-interacting protein 1, DAB2-interacting protein, DOC-2/DAB-2 interactive protein, disabled 2 interacting protein …
WebClinVar archives and aggregates information about relationships among variation and human health. the barn golborneWebOct 4, 2016 · By interacting with other cellular factors through these motifs, Dab2 elicits its functions in endocytosis, differentiation, and immune response and is involved in the cell signaling pathways of Ras-mitogen activated protein kinase (MAPK), Wnt, TGF-β, c-Src and RhoA-ROCK [24, 27–36]. the gym 8th and mainDAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction domain. The down-regulation of DAB2 may play an important role in ovarian carcino… the barn golf clubWebJul 15, 2016 · Overall, Dab2 acts as a scaffold protein by interacting with many, but not all, cargo receptors, and by establishing simultaneous contacts at the site of endocytosis, favoring recruitment of other adaptor proteins that are essential for endocytosis to occur. Disabled‐2, an obligatory intermediary in developmental processes the gym aberdeenWebDOC-2/DAB2 interacting protein (DAB2IP) is a RasGAP protein that shows a suppressive effect on cancer progression. Our previous study showed the involvement of transcription regulation of DAB2IP in metastasis of colorectal cancer (CRC). However, the molecular mechanisms of DAB2IP in regulating the progression of CRC need to be further explored. the gym 6 weeks freeWebSep 17, 2024 · Meanwhile, the DOC-2/DAB2 interacting protein DAB2IP was previously identified as a member of the Ras-GTPase activating protein family, and functions as a tumor suppressor in cancer progression 7,8. the barn golf course utahWebFeb 15, 2024 · Disabled-2 (Dab2/DOC-2) is a mitogen-responsive adaptor protein required for multiple cellular functions. It is involved in many signaling pathways and plays an integral role in vesicular uptake and trafficking, modulating immune function, protein–protein interactions, cellular homeostasis and differentiation, oncogenesis, and inflammatory … the gym aberdeen hair