WebbThe pathogenesis of idiopathic pulmonary fibrosis (IPF) involves a complex interplay of cell types and signaling pathways. Recurrent alveolar epithelial cell (AEC) injury may occur in the context of predisposing factors (e.g., genetic, environmental, epigenetic, immunologic, and gerontologic), leading to metabolic dysfunction, senescence, aberrant epithelial … Webb29 aug. 2024 · These findings overthrow a long-held view about how epithelial cells themselves kickstart the healing response after injury. The authors believe these results could have implications for several autoimmune conditions, including inflammatory bowel disease and psoriasis, where IL-17a plays a central role.
Kidney fibrosis: from mechanisms to therapeutic medicines
Webb29 mars 2024 · Herein, a novel lncRNA lnc001776 expression was confirmed to be substantially elevated in the ileum tissue of CpC-infected diarrhea piglets and in CPB2 toxin-treated porcine small intestinal epithelial cells (IPEC-J2). lnc001776 knockdown restrained CPB2 toxin-induced apoptosis, inflammatory injury, barrier dysfunction and … WebbEpithelialisation is the formation of epithelium over a denuded surface. Epithelialisation of an incisional wound involves the migration of cells at the wound edges over a distance … health plus access
Primary proximal tubule injury leads to epithelial cell cycle arrest ...
Webb26 apr. 2013 · ABSTRACT Induction of epithelial–myofibroblast transition (EMyT), a robust fibrogenic phe-notype change hallmarked by α-smooth muscle actin (SMA) expression, requires transform-ing growth factor-β1 (TGFβ) and the absence/uncoupling of intracellular contacts. This sug-gests that an “injured” epithelium may be topically … Webb7 okt. 2024 · Immunosurveillance at barrier tissues plays a crucial role in maintaining the integrity of the epithelial surface, defending against pathogens, and facilitating repair following injury. Over-suppression or over-activation of the immune system can lead to delayed wound healing or pathological inflammation, respectively. Webb1 feb. 2001 · First, epithelial cells adjacent to the injured surface migrate into the wound to cover the denuded area. Those epithelial cells that migrate into the wound defect dedifferentiate, form pseudopodia-like structures, reorganize their cytoskeleton, and redifferentiate after closure of the wound defect. good discord text channels