Plk1 breast cancer
Webb27 feb. 2024 · Since Plk1 is required for tumor cell proliferation, the authors showed that rigosertib induced apoptotic activity against 94 tumor cell lines with a GI 50 between 50–200 nM, resulting in tumor cell death by mitotic arrest, demonstrating its potential efficacy. Notably, this cytotoxic effect was not observed in non-tumoral cells. Webb11 apr. 2024 · However, in vivo studies have shown antitumor activity in breast cancer (MCF7) and prostate adenocarcinoma cell-based assays . This relationship works by inducing cell proliferation through the reduction of Aurora B activity, causing mitotic deficiencies, and eradicating the checkpoint proteins hBUBR1 and CENP-E from the …
Plk1 breast cancer
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Webb15 okt. 2024 · Polo-like kinase 1 ( PLK1 ), the most investigated member of the PLK … Webb14 apr. 2024 · University of Cincinnati Cancer Center researchers will present more than a dozen abstracts at the American Association for Cancer Research Annual Meeting 2024, held in Orlando, Florida, April 14 ...
Webb15 juli 2024 · Polo-like kinase 1 (PLK1) is a protein kinase that is overexpressed in breast cancer and may represent an attractive target for breast cancer treatment. However, few studies have investigated the relationship between PLK1 … WebbBackground and Purpose: Over the last decade, the inhibition of PLK1 has proven potent …
WebbTherefore, the simultaneous delivery of PTX and PLK1-targeted siRNA using AS1411 aptamer-functionalized liposome may have good potential clinical value for the therapy of breast cancer. Nanomedicine based on simultaneous delivery of chemotherapy drugs and siRNA gene provides an effective platform for improving tumor treatment methods. Webbför 9 timmar sedan · Sarah Beeny, the broadcaster and property expert, has announced …
Webb23 juli 2024 · The mitotic phenotype of cells expressing the same variant was studied by Ehlén and colleagues, which led to the finding that BRCA2 is phosphorylated at this residue by PLK1 in mitosis, promoting chromosome alignment and faithful segregation; a mechanism that appears uncoupled to the interphase function of BRCA2 [ 17 ]. Table 2.
Webb15 juli 2024 · Mechanistically, PLK1 inhibition led to the downregulation of radiation … ticwatch pro 4g twrpWebbInhibition of PLK1 contributes cell cycle G2-phase arrest and inhibits the proliferation, migration, and apoptosis of gastric cancer (GC) cells, whereas its overexpression promotes proliferation, migration, and apoptosis in these cells. Moreover, PLK1 inhibition reduces expression of pMEK and pERK. the lutheran church of our savior buffalo nyWebb6 feb. 2012 · PLK1 was universally expressed in breast cancer cell lines, representing all of the breast cancer subtypes, and was positively correlated to CD44. The PLK1 inhibitor BI 2536 showed similar effects on growth, mammosphere … the lutheran digestWebb14 apr. 2024 · CCNE1 and PLK1 Mediate Resistance to Palbociclib in HR+/HER2− Metastatic Breast Cancer Clinical Cancer Research American Association for Cancer Research Skip to Main Content Advertisement Close AACR Journals Blood Cancer Discovery Cancer Discovery Cancer Epidemiology, Biomarkers & Prevention Cancer … the lutheran church of the triune godWebbIn addition to PLK1 and PLK2, the structurally distinct isoform PLK4 (with only one polo-box instead of two) was also found to be overexpressed in triple-negative breast cancer with basal-like subtype and upregulation of PLK4 causes centriole overduplication. 159,160 Several potent and selective PLK4 inhibitors have been reported and tumor growth … the lutheran church of the holy spiritWebb14 apr. 2024 · AbstractPurpose:. In hormone receptor–positive (HR+)/HER2− metastatic … the lutheran church of saint luketicwatch pro 4g 刷机