WebSome studies have shed new light on the relationship between excess TSH, hepatic gluconeogenesis, and insulin resistance. TSH inhibits cAMP-regulated transcriptional coactivators 2 (CRTC2) phosphorylation and upregulates p-CREB (cAMP-response element binding protein) by activating the TSHR/cAMP/ protein kinase A (PKA) pathway. WebJan 8, 2024 · Anti-TSH Receptor (TSHR) (extracellular) Antibody (#ATR-006) is a highly specific antibody directed against an epitope of the rat protein. The antibody can be used in western blot analysis. The antibody recognizes an extracellular epitope and thus is ideal for detecting the receptor in living cells. It has been designed to recognize TSHR from ...
Anti-TSHR Antibody (2C11) SCBT - Santa Cruz Biotechnology
WebThe Creative Biolabs cAMP Maxensor TSHR cell line is designed to test compounds or analyze their ability to modulate thyroid-stimulating hormone receptors. When the agonist binds to TSHR, it activates the G protein, which in turn triggers a cellular response mediated by cAMP. This cell line has been verified by analyzing the intracellular ... WebRecombinant Human TSHR Protein (Gly21-Gly413) ECD 17299-H08B with a fusion His Tag, is expressed in Baculovirus-Insect Cells. With high purity, high biological activity, high … lyft canberra
TSH Receptor Antagonists Agonists MedChemExpress
WebOct 28, 2024 · Abstract. (GPCR)The receptor for TSH receptor (TSHR), a G protein coupled receptor (GPCR), is of particular interest as the primary antigen in autoimmune hyperthyroidism (Graves’ disease) caused by stimulating TSHR antibodies. To date, only one domain of the extracellular region of the TSHR has been crystallized. WebThyrotropin receptor (UniProt: P16473; also known as Thyroid-stimulating hormone receptor, TSH-R) is encoded by the TSHR (also known as LGR3) gene (Gene ID: 7253) in human. TSH-R is a multi-pass membrane protein of ... TSHR; Purification Method: Protein G purified: UniProt Number: P16473; Molecular Weight: 86.83 kDa calculated. Physicochemical ... WebMar 5, 2024 · Lineage. Also known as. LGR3; CHNG1; hTSHR-I. Summary. The protein encoded by this gene is a membrane protein and a major controller of thyroid cell … lyft can you schedule a ride ahead of time